By Victor Parsons
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Additional info for A Colour Atlas of Bone Disease (Wolfe Medical Atlases)
Any tubular bone may be involved but the most common site is around the knee joint in the metaphysis of the femur and tibia. The neoplasm arises in the medullary cavity and erodes the cortex to give a sharply outlined radiolucent area with a thin sclerotic border (210). 210 Chondromyxoid fibroma Histologically, the lesion consists of lobules of chondromyxoid tissue separated by fibrous connective tissue. Some areas may differentiate into cartilage. Scattered multinucleated giant cells and large pleomorphic cells may be present.
The osteocyte and osteoblast are responsible for the simultaneous excretion of the protein matrix and the crystal nuclei which make up the two elements of bone (77). microscopy X 200). Up . to the age of 60 years about 80 per cent of the bone osteoid surface is associated with a potential calcification front. 77 Cellular calcification mechanisms vitamin D affects proteinsynthesis mino acids tamin uptake - Fe++ ~ g~~~~t~fand calcium mineral ~ ri <> P04 g calcification I t 0 0 moderators MPs P-P matrix t )ca nucleation ,0.
Quantitation bone of the metabolic status of Iliac crest bone is commonly used in the diagnosis of bone disease. Quantitative measurement enables not only a diagnosis to be made but also an assessment of the severity of the disease and its eventual response to treatment. The biopsy is taken in a standard fashion (79) and preserved from deformation. The ideal site for biopsy is shown in 80. A large trephine is used (81) so that a cylinder of bone is obtained which includes outer and inner tables of compact bone.
A Colour Atlas of Bone Disease (Wolfe Medical Atlases) by Victor Parsons